When it comes to the architecture of the human genome, it’s only a matter of time before harmful genes — genes that could compromise future generations — arise in a population. These mutations accumulate in the gene pool, primarily affected by a population’s size and practices like marrying within a small community. New research published in the Proceedings of the National Academy of Sciences (PNAS) journal provides rare direct evidence showing that increased homozygosity — meaning two identical alleles in a genome — leads to negative effects on fertility in a human population.
From pocketed headphones to carelessly packed garden hoses, knots find ways to manifest. Even our DNA molecules get tied in knots too. Professor Mariel Vazquez applies her training in mathematics to fundamental questions about DNA structure and functionality.
For the past decade, genetic researchers from the Henn Lab have worked among the Khoe-San and self-identified “Coloured” communities in South Africa, requesting DNA and generating genetic data to help unravel the history and prehistory of southern Africans and their relationship to populations around the world. However, the researchers have been unable to fulfill a common request: providing them their individual genetic ancestry results. What they found is that there is no easy answer.
The transition of human societies from hunter-gatherers to farmers and pastoralists is a more nuanced process than generally thought, according to a new study of peoples living in the highlands of southwest Ethiopia. The work was published March 9 in Current Biology.
The Tibetan Plateau has long been considered one of the last places to be populated by people in their migration around the globe. A new paper by archaeologists at UC Davis highlights that our extinct cousins, the Denisovans, reached the “roof of the world” about 160,000 years ago — 120,000 years earlier than previous estimates for our species — and even contributed to our adaptation to high altitude.
Inuit sled dogs have changed little since people migrated with them to the North American Arctic across the Bering Strait from Siberia, according to UC Davis researchers and colleagues who have examined DNA from the dogs from that time span. The legacy of these Inuit dogs survives today in Arctic sled dogs, making them one of the last remaining descendant populations of indigenous, pre-European dog lineages in the Americas.
Students from any major on campus can engage in undergraduate research in the UC Davis College of Letters and Science. As a senior, Cole Williams pursued his interests in genetics with a project in the lab of Brenna Henn, associate professor of anthropology.
Study finds that a gene for lighter skin spread rapidly among people in southern Africa in the last 2,000 years. University of California, Davis, researchers and colleagues report that the gene was introduced from eastern Africa to southern African populations. Strong positive selection caused this gene to rise in frequency among some KhoeSan populations.